deltaDOT’s Iohexol measurement assay is compared favourably against other methods for detection of reduced kidney function in dogs by an independent study

Press release:  14th November 2019

The Royal Veterinary College (RVC) publishes the results of 5 year comparison study showing how data from deltaDOT’s assay compares favourably against other commonly used diagnostic tests for kidney function in dogs (measurement of SDMA and creatinine).

Nigel Stokes. deltaDOT’s Managing Director commented “RVC’s publication shows how our advanced Capillary Electrophoresis instruments have been used to accurately measure Iohexol concentrations in canine serum over the past 5 years. This has enabled us to accurately and inexpensively calculate the GFR (Glomerular Filtration rate) of the dog much more accurately. GFR is considered by many to be the “gold standard” measure of kidney function. The benefit of using CE is because there is no need to remove the serum proteins as they can flow through the capillary. This is not the case for other commonly used techniques such as HPLC which require the proteins to be removed to avoid column blockage. When compared to traditional single point CE, the deltaDOT technology has further significant advantages as it used multi-pixel detection. Unlike traditional CE and HPLC instruments which measure the analyte peak with just one detector, the deltaDOT system uses 512 pixels. When the readings from all 512 pixels are averaged the accuracy of our data (in terms of quantitation) are significantly better than for other techniques. The greater precision of the Iohexol measurements at the time points enables deltaDOT’s instruments to more accurately calculate the Glomerular Filtration Rate (GFR).”

For further information on the above study, and to download the paper, please visit our Veterinary Diagnostics page at: